Acţiunea in vitro a preparatelor BioR şi BioRZn asupra tabloului clinic şi activităţii funcţionale a limfocitelor T la bolnavii cu reacţii adverse la preparatele antituberculoase
Închide
Conţinutul numărului revistei
Articolul precedent
Articolul urmator
934 1
Ultima descărcare din IBN:
2020-02-27 16:44
SM ISO690:2012
GHINDA, Serghei; RUDIC, Valeriu; CHIRIAC, Tatiana; CHIROŞCA, Valentina; BRUMARU, Albina. Acţiunea in vitro a preparatelor BioR şi BioRZn asupra tabloului clinic şi activităţii funcţionale a limfocitelor T la bolnavii cu reacţii adverse la preparatele antituberculoase. In: Curierul Medical. 2013, nr. 5(56), pp. 127-130. ISSN 1875-0666.
EXPORT metadate:
Google Scholar
Crossref
CERIF

DataCite
Dublin Core
Curierul Medical
Numărul 5(56) / 2013 / ISSN 1875-0666

Acţiunea in vitro a preparatelor BioR şi BioRZn asupra tabloului clinic şi activităţii funcţionale a limfocitelor T la bolnavii cu reacţii adverse la preparatele antituberculoase

Pag. 127-130

Ghinda Serghei1, Rudic Valeriu2, Chiriac Tatiana2, Chiroşca Valentina1, Brumaru Albina1
 
1 IMSP Institutul de Ftiziopneumologie „Chiril Draganiuc“,
2 Institutul de Microbiologie şi Biotehnologie al AŞM
 
Disponibil în IBN: 10 martie 2014


Rezumat

The purpose of our research is to study the in vitro action of the drugs BioR and BioRZn (a complex of essential bioactive zinc components in spirulina) on the clinical picture and full functional activity of T-lymphocytes, depending on the adverse effects of antituberculosis drugs. For processing the materials the operating methods of statistical estimation, including the Student’s criterion, Windows 2007 software, etc. have been used. The study has included 110 patients of both sexes with various forms of pulmonary tuberculosis. Depending on the reaction to anti-tuberculosis preparations, the patients were divided into three groups: 1) allergic reaction (AR) – 37 patients, 2) toxic-allergic reactions (TAR) – 49 patients and 3) the patients with toxic reaction (TR) – 24 people. To characterize the state of proliferation activity of T lymphocytes the reaction of blast transformation of lymphocytes with phytohaemaglutinin has been used. The patients with allergic, toxic-allergic and toxic reactions on antituberculosis preparations have demonstrated clinical and laboratory differences, that confirm the severe disease progression in the patients with toxic reactions and less severe disease progression in the patients with allergic reactions. BioR preparations and, especially, BioRZn present the immunomodulatory action of T lymphocytes ”in vitro”. The lower the level of proliferation activity of T lymphocytes in patients is, the higher the immunomodulatory activity of preparations BioR and, in particular, BioRZn in the process of proliferation of T lymphocytes and vice versa is.

Cuvinte-cheie
T lymphocytes, anti-tuberculosis chemotherapy.