This scientific article discusses particularities of modern evolution of epidemic process of viral hepatitis B, C and D in the Republic of Moldova. Three national programs for viral hepatitis B, C and D prevention have been implemented in the Republic of Moldova. As a result of the introduction of these programs the morbidity of parenteral viral hepatitis has decreased significantly, but the implementation of all preventive measures is necessary for viral hepatitis diminution. In order to further reduce the incidence of acute viral hepatitis to the indicators registered in most European countries and the incidence of chronic hepatitis, cirrhosis and primary liver cancer, as well as to improve the epidemiological situation and the health status of the population of the Republic of Moldova and to reduce the economic impact the Ministry of Health together with the National Centre of Health has developed a National Program on the fight against viral hepatitis B, C and D for 2012-2016. The materials and results of the research on the epidemiology of viral hepatitis, conducted over a period of many years by the staff of the laboratory of the National Centre of Public Health, have been used. The epidemiological, analytical and statistical methods have been applied in the study.