Diverse forme de trombofilii au un rol patologic în geneza unui număr mare de complicații ale sarcinii: infertilitate, FIV eşecuri, avorturi în termeni mici , restricţie de creştere intrauterină a fătului, preeclampsie, moartea fetala antenatală a fătului etc. Un rol special revine asocierilor dintre trombofilii şi disfuncţiile endoteliale, care servesc drept fundal patogenetic pentru progresarea complicaţiilor sarcinii.

The are a pathological role of different forms of thrombophilia in the pathogenesis of a great number of complications of pregnancy: infertility, pre-embryonic losses, IVF failures, early miscarriages, intrauterine growth restriction, preeclampsia, premature rupture of normally located placenta, antenatal fetal death, preterm labour, stillbirth. The special role is devoted to the association of thrombophilia and endothelial dysfunction, which serve as a pathogenetic background for the progression of pregnancy complications.