Eugen Simion şi utopia literaturii(note sentimentale la sărbătorirea unui mare critic)
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CREŢU, Bogdan. Eugen Simion şi utopia literaturii(note sentimentale la sărbătorirea unui mare critic). In: Limba Română . 2013, nr. 7-8(218), pp. 109-115. ISSN 0235-9111.
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Limba Română
Numărul 7-8(218) / 2013 / ISSN 0235-9111

Eugen Simion şi utopia literaturii(note sentimentale la sărbătorirea unui mare critic)

Pag. 109-115

Creţu Bogdan
 
Academia Româna
 
Disponibil în IBN: 12 decembrie 2013


BibTeX Export

@article{ibn_104524,
author = {Bora, A. and Crisan, L. and Avram, S. and Pacureanu, L. and Borota, A. and Kurunczi, L.},
title = {<p>The investigation of chemical space of COX-2, GSK-3 and CDK-2 inhibitors - a hope for the treatment of colon cancer</p>},
collection = {Physical Methods in Coordination and Supramolecular Chemistry},
year = {2012},
volume = {XVII},
pages = {55-55},
abstract = {(EN) <p>The study of cyclooxygenase-2 (COX-2), glycogen synthase kinase-3 (GSK-3) and cyclin-dependent kinase-2 (CDK-2) has been intensified over the last few years because of their involvement in essentially all major physiological pathways and of their implications in many human diseases. In this paper, we report the investigation of various compounds from ChEMBL database [1] (containing more than 1.2 million small molecule compounds) using Instant JChem tool [2] against the COX-2, GSK-3 and CDK-2 targets. Our approach clearly identified one molecule (ID Code: ChEMBL50 as quercetin) from ChEMBL database as being the unique common structure against all three targets. According to the activity classification criteria (IC50&le;2000nM as potentially active compound; IC50=2000-20000nM as medium potentially active compound and IC50&gt;20000nM as inactive compound [3]), the ChEMBL50 compound (IC50 of 40000nm, 28000nm against CDK-2 and COX-2, and IC50 of 2100nm against GSK-3) cannot be evaluated as potential inhibitor against discussed targets. In these conditions, we repeated the search based on substructure search template and nineteen potential inhibitors against CDK-2, GSK-3 and COX-2 were detected. The present study states the importance of small molecule libraries and their use to enhance the drug discovery process.</p>},
url = {https://ibn.idsi.md/vizualizare_articol/104524},
}