Teoria infecţiei focale a fost o sursă de frustrare şi inspiraţie de‑a lungul timpului, atât în practica dentară cat şi în cercetare. Infecţia focala a fost implicata in diseminarea patogenilor in întreg organismul. In acest studiu am examinat pacienţii afectaţi de diferite boli generale, care au prezentat bacteriemii apărute in cursul tratamentelor endodontice. La aceşti pacienţi am găsit o legătura strânsă intre procesele patogene din afecţiunile parodontale marginale si periapicale. La pacienţii cu endocardite infecţioase, reumatism articular acut sau diabet trebuie instituit si un tratament antibiotic in corelaţie cu cel stomatologic.

The focal infecion theory has been a source of both frustation and inspiration in dental practice and research. Focal infection originally implied dissemination of pathogens from the focus to remote part of the body, where secondary disease arose. In this study the patients which we examinated had a general health compromised and their teeth had a bacteremias during endodontic treatment. At these patients is the great similarity between the pathogenic process in marginal and apical periodontitis. A history of infective endocarditis, rheumatic heart fever or diabetic disease, may necessitate the implementation of antibiotic regimen in conjunction with the endodontic procedures to these patients.