Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
849 7 |
Ultima descărcare din IBN: 2022-01-14 12:08 |
SM ISO690:2012 COBEŢ, Valeriu. Third generation of statins: effects compared in clinical studies. In: Curierul Medical, 2013, nr. 3(56), pp. 44-51. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 3(56) / 2013 / ISSN 1875-0666 | ||||||
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Pag. 44-51 | ||||||
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Accordingly to data obtained in many large clinical studies especially belonging to Galaxy project rosuvastatin, the most recent statin has demonstrated, comparatively to atorvastatin, a stronger hypolipemiant effect emphasized thereby the circulating levels of total, LDL- and HDL cholesterol, triglycerides, apo-A, apo-B and apo-B/apo-A ratio as well as concerning the number of patients achieving lipid indices target. Rosuvastatin influenced better also the endothelial dysfunction, evidences basically being linked to atherosclerotic plaque regression, nonspecific systemic inflammation response, artery intimamedia thickness and flow meditated artery dilation. A lower lipophilicity of rosuvastatin than atorvastatin is an important support ensuring a lesser risk of adverse affects such as: insulin secretion fall and insulin resistance boosting, rhabdomyolysis, myotixicity, cognitive dysfunction and insomnia. |
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Cuvinte-cheie rosuvastatin, hypolipemiant and pleiotropic effects, atorvastatin |
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