Cyclodextrins – fields of application. part II
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DUKA, Gh., IVANCIC, Albert, BOLDESCU, Veaceslav. Cyclodextrins – fields of application. part II. In: Chemistry Journal of Moldova, 2012, nr. 2(7), pp. 39-45. ISSN 1857-1727.
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Chemistry Journal of Moldova
Numărul 2(7) / 2012 / ISSN 1857-1727 /ISSNe 2345-1688

Cyclodextrins – fields of application. part II

Pag. 39-45

Duka Gh.1, Ivancic Albert2, Boldescu Veaceslav2
 
1 Academy of Sciences of Moldova,
2 Moldova State University
 
Disponibil în IBN: 14 decembrie 2013


Rezumat

This paper represents an analysis of potential and current applications of cyclodextrins as biologically active substances in medicine. The main applications described here include use of cyclodextrins as agents that form inclusion complexes with endogenous substances (membrane lipids, cellular cholesterol), agents that form inclusion complexes with exogenous substances with their man role as guest molecules (sugammadex, FBCx), agents that block endogenous and exogenous macromolecules (ion channels, anthrax toxin, α-hemolysin), and agents which activity is based on the chemical nature of them and of their derivatives (cyclodextrin polysulphate derivatives). The fi rst classification for medically important biological activity of cyclodextrins has been proposed.

Cuvinte-cheie
cyclodextrins, pharmaceuticals, medicine,

inclusion complexes.