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SM ISO690:2012 CHEPTEA, Eduard, GONCIAR, Veaceslav. Unele aspecte metabolice ale interacţiunii derivaţilor izotioureici cu oxigenul hiperbaric. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 379-388. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | |||||
Numărul 1(11) / 2010 / ISSN 1857-1719 | |||||
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Pag. 379-388 | |||||
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In the experiments on rats the aspects of the isothioureic derivatives interaction with hyperbaric oxygen (HBO) on the lipid metabolism level was studied. HBO (6 ata 50 min) caused the increase of plasmatic concentration of total lipids, total phospholipids, total cholesterol, esterified cholesterol, fatty nonesterified acids, total lipoproteins, α γ-lipoproteins, β-lipoproteins, cholesterol of lipoproteins. Izoturone (20 mg/kg) in normobaric conditions provoked the decrease of the content of total lipids, fatty nonesterified acids and the increase of total lipoproteins cholesterol and β-lipoproteins cholesterol. Diphetur (20 mg/kg) in normobaric conditions caused the increase of the level of total lipids and decrease of total lipoproteins, α γ-lipoproteins, β-lipoproteins and their cholesterol. A complex metabolic interaction on the level of lipidic and lipoproteinic metabolism on the simultaneous prescription of izoturone, diphetur and HBO was revealed. In majority of cases the izoturone, the diphetur and the HBO reciprocally normalized the modification of parameters of lipidic metabolism, in others pharmacological agents act similarly manifasting a tendency of effects accumulation. |
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