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SM ISO690:2012 MAZURU, Vitalie. Dinamica expresiei factorului de creştere al endoteliului vascular-c în leziunile preneoplazice şi neoplazice de cervix uterin. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2010, nr. 1(11), pp. 143-149. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(11) / 2010 / ISSN 1857-1719 | ||||||
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Pag. 143-149 | ||||||
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The spreading throughout the body of neoplastic cells, using different ways, is a characteristic hallmark for malignant tumors. The main importance of the lymphovascular route for metastasizing is well known for a long period of time. Discovering of the lymphatic vessels markers allowed scientists to understand more detailed the mechanisms of this phenomenon. It has been well established that VEGF-C (vascular endothelial growth factor-C) can induce the proliferation of lymphatic endothelial cells. The aim: to study the features of the VEGF-C expression during the progression of the uterine cervix neoplasia. Material and methods: the study was performed on 22 cases of squamous metaplasia, CIN I – 14; CIN II – 12; CIN III – 6; microcarcinoma – 15; invasive carcinoma – 32 cases. PT-Link LSAB immunohistochemical method was performed using anti VEGF-C (clone SC9047, Santa Cruz, USA, dilution 1:100) as a primary antibody. Results: the less numerous cases of positive reaction for VEGF-C were found in squamous metaplasia (27.28%). The numbers of positive anti VEGF-C cases increasing were dependent of stage of cervical lesion. In the invasive carcinoma stage all cases were positive for VEGF-C. The intensity of the VEGF-C expression was heterogeneous, but in the area of the invasive edge was strong in 100% cases. Conclusions: the intensity of the VEGF-C expression correlates with the stage of uterine cervix neoplasia progression. Vascular invasion is strongly associated to intensive expression of VEGF-C. |
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