Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
870 5 |
Ultima descărcare din IBN: 2023-07-12 22:32 |
SM ISO690:2012 ICHIM, Andrei. Aspecte genetice ale insuficienţei cardiace. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2008, nr. 3(9), pp. 94-98. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(9) / 2008 / ISSN 1857-1719 | ||||||
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Pag. 94-98 | ||||||
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Heart failure represents a major cause of disease burden worldwide and is expected to further rise in the coming decades. Beta-blockers (metoprolol, bisoprolol, and carvedilol) are a cornerstone of heart failure (HF) treatment. However, it is well recognized that responses to a beta-blocker are variable among patients with HF. Neurohormonal activation is an important driver of heart failure progression, and all pharmacologic interventions that improve clinical outcomes inhibit this systemic response to myocardial injury. Numerous studies now suggest that genetic polymorphisms may contribute to variability in responses to a beta-blocker, including left ventricular ejection fraction improvement, survival, and hospitalization due to HF exacerbation. |
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