The main goal of this study was to histologically evaluate the regeneration of bone tissue in case of fractures. According to the type of mechanical stabilization applied, the bone consolidation undergoes whether endochondral, or intramembranous ossification. Each mechanism includes several stages, histologically and physiologically different. They ensure the arrival of osteoprogenitor cells at the site of the fracture and their activation, realized by inductive factors. Tissue engineering, that is implantation of biological or artificial material which creates a proper environment for bone regeneration, presents a new and promising field in fracture surgery.