Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
929 9 |
Ultima descărcare din IBN: 2024-04-02 15:33 |
SM ISO690:2012 MORARU, Ion. Stresul oxidativ în afecţiunile cardiovasculare. In: Curierul Medical, 2013, nr. 1(56), pp. 65-72. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 1(56) / 2013 / ISSN 1875-0666 | ||||||
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Pag. 65-72 | ||||||
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Oxidative stress is recognized as a universal feature of many diseases, including cardiovascular disorders. In this article, the main pathogenic mechanisms of oxidative stress regarding heart failure and arterial hypertension evolution are underlined. The role of free oxygen radicals in myocardial hypertrophy
development as well as their importance in extracellular matrix reorganization are emphasized. Likewise, the molecular and cellular substrate of crosslink between oxidative stress and cell apoptosis and inflammation are estimated. The contribution of oxidative stress on arterial hypertension evolution is
basically observed through targeting of vascular endothelium especially concerning nitric oxide depletion, inflammatory response, and compromising of vascular endothelium dependent reactivity. Thus, activation of grow and transcription factors, cytokines, caspases and matrix metalloproteinases are
most important mechanisms in oxidative stress induced heart failure, while the vascular endothelium and nitric oxide synthesis impairment are basically involved in arterial hypertension evolution. |
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Cuvinte-cheie oxidative stress, heart failure, arterial hypertension. |
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