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Ultima descărcare din IBN: 2018-06-05 22:04 |
SM ISO690:2012 CIOBANU, Victoria, COTELEA, Tamara, LÎSÎI, Leonid. Riscul de intoxicaţie cu aminofilină şi condiţiile optime de analiză chimico-toxicologică
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2008, nr. 1(9), pp. 310-313. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(9) / 2008 / ISSN 1857-1719 | ||||||
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Pag. 310-313 | ||||||
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Contribution in studying chemical-toxicology of aminophylline in biotransformation process
The main idea of this work was to develop physical-chemical methods by investigation theophylline Isolation tests from biological liquids were affected in PH diversions. Results confirmed by thin layer of chromatography pplication.Application of mobile phases of methanol-sol.ammonium25% (100-1.5) with Rf 0.75,and UV spectrophometry with maximum absorbtionby wave length 275 nm, IR spectroscopy (suspension in oil of Vaseline ) with band absorbtion 1670,1717,1567,715,980 cm (KBr) Identification of theophylline was determined by HPLC method.This method implicates coloumn C 18 Lichrospher 100-RP-18C with precoloun Lichrocort-124-4 in mobile phase trietilamine 146 μl , Phosphoric acid 750 μl, Water till 530 ml,PH-3,3 with Na0H solution 10% and apply Acetonitril till 750 ml. Current rate
is 0.6 ml/min |
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