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SM ISO690:2012 LEVIŢCHI, Alexei, GALEA-ABDUȘA, Daniela, DUCA, Maria. Exploratory analysis of gene microarray datasets for molecular diagnosis. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2012, nr. 3(13), pp. 57-62. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(13) / 2012 / ISSN 1857-1719 | ||||||
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Pag. 57-62 | ||||||
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The aim of the investigation was exploratory analysis of the free available expression microarray datasets for the identification of candidate genes hypothetically involved in manifestation of cardiovascular diseases. Applying developed methodology, there was determined a set of 6088 of candidate genes. These findings were validated through two sets of genes: cardiovascular priority genes and associated genes. It showed that 10 per cent of the genes belong to one of the list, while the other represents a set of special interest to be demonstrated their involvement in cardiovascular diseases. To be noted more then 2000 genes have no annotation and their functions still need to be clarified. This set of genes potentially can be applied for the development of a cardio-chip for the molecular diagnosis of various CV pathologies. |
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