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SM ISO690:2012 GARIT-BREGA, Diana, SPINEI, Larisa. Programul screening-ului şi monitoring-ului familiilor canceroase în Republica Moldova. Cercetarea rudelor asimptomatice . In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2012, nr. 2(13), pp. 389-398. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 2(13) / 2012 / ISSN 1857-1719 | ||||||
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Pag. 389-398 | ||||||
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The screening and monitoring programme of the cancer families in the Republic
of Moldova. Investigation of the asymptomatic relatives of the pacients
Individuals having high family risk (there are 3 and more cases of the malignant neoplasms registered in the family) need special screening approach, in comparison with those, having the moderate risk and requesting standard screening.
Among the 278 investigated relatives from 163 families having a non-complicated oncological anamnesis, different pathologies were found out at 78 (28.0%) of people. This pathology was prevailingly represented by colorectal adenomas (13.3%) and other benign tumors (12.6%) The rate of malignant neoplasms among the immediate relatives formed 2.3%.
In those 74 families having a complicated oncological anamnesis in which, there were 2 and more cases of NFM, among the immediate relatives except the probands who were not formally referred to anyone of the mentioned syndromes; the frequency of finding out the pre-cancerous and cancerous pathologies at the immediate relatives was considerably high – 44.8 % Among the immediate relatives in these families the CCR was found in 11(10.3%) cases, NMPM – in 3(2.8%), CEM, CGM and other NFM in 1(0.9%) cases. The colorectal adenomas were found at 19 (17.7%) patients.
The highest rate per cent of finding the NFM was marked in the families with the classic syndrome of HNPCC. From the 45 asymptomatic immediate relatives of the probands with the HNPCC syndrome, via colonoscopic investigations 29 (64.4%) cases found to have colorectal pathology: 11(24.4%) – solitary and multiple adenoamas colorectal and at 18(37.7%) too. The increasing rate per cent of finding the malignant neoplasms among the members of the families, having a complicated hereditary-collateral anamesis, requires the necessity of the screening at
these people, with a purpose of early finding out the incipient cancer forms and secondary prevention of cancer.
The dates obtained during the investigation can be used as a base for the elaboration of the screening algorithm of the asymptomatic relatives of the patients with PTK, cancer of the reproductive system organs at the women and primary-multiple malignant neoplasms (NMPM). |
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