In this mini-review, we describe some of the latest facts regarding the generation of condensed base phonons by biological entities, initially described by the renowned contemporary physicist, Nobel laureate, Herbert Fröhlich, who proposed a new biophysical interaction mechanism between extremely high frequency electromagnetic waves and the biological environment. As we will show, this extremely low intensity millimeter therapy crystallizes as an important new method, universal and effective in the management of diseases with different etiologies. Moreover, the existence of internal electromagnetic fields generated by biological entities, as well as external electromagnetic fields, are essential for understanding the electromagnetic-biological effect. In fact, it is estimated that at present millimeter-wave therapy is used for the management of more than 120 diseases in cardiology, neurology, oncology, gynecology, urology, gastroenterology, surgery, pharmacology and pediatrics. However, so far there is still no consensus regarding the interaction between extremely high frequency/extremely low intensity electromagnetic waves and the biological environment at its different levels of organization. Thus, the present paper was intended to contribute to the development for the theory of millimeter-wave interaction with living biological entities.