Correlation between activity of C- reactive protein (CRP) and ceruloplasmine in haemorrhagic shock revived with hyaluronic acid Haemorrhagic shock is manifested through local and diffuse inflammatory process. The pathogenetic factors of systemic inflammation are acute phase proteins and oxygen free radicals. CRP and ceruloplasmine are recognized as markers of loyal local and diffuse inflammatory process. Postinfusionale syndrome triggers a set of tissue damages additional to hypovolemic impact, which are assign to reperfuse syndrome, and are mediated by oxidative stress, and respectively , detremental affected by acute phase proteins, proinflammatory cytokines, metals and modulators proteins of oxidative stress ( transferine-iron, ceruloplasmine-copper).

Şocul hemoragic se manifestă prin proces inflamator local şi difuz. Factorii patogenetici ai inflamaţiei sistemice sunt proteinele fazei acute şi radicalii liberi de oxigen. PCR şi ceruloplasmina sunt recunoscuţi drept markeri fideli ai procesului inflamator local şi difuz. Sindromul postinfuzional declanşează un set de alterări tisulare adiţionale impactului hipovolemic, care sunt atribuite efectului de reperfuzie şi sunt mediate predilect prin stresul oxidativ şi, respectiv, influenţate detrimental de către proteinele fazei acute, citokinele proinflamatoare, metalele şi proteinele modulatoare a stresului oxidativ (transferina – fierul, ceruloplasmina – cuprul).