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SM ISO690:2012 RUDICO, Lucian. Rolul papilomavirusurilor în apariţia neoplaziilor epiteliale. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2012, nr. 1(13), pp. 54-62. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(13) / 2012 / ISSN 1857-1719 | ||||||
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Pag. 54-62 | ||||||
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Role of papillomaviruses in development epithelial neoplasia
It is demonstrated that papillomaviruses are ethyological factors of crucial importance in appearance and progression of epithelial neoplastic lesions. In spite of their heterogenity and polymorphism, these causal agents are able to infect epithelial sites of the species. In case of humans they may provoke abortive infections, usually with no clinical expression. In case of concomitant infections papilomaviruses may lead to neoplasia with high risk of malignant transformation. Papillomaviruses affect exclusively epithelia, using identical mechanisms of invasion, differences being represented by the ability of the viral genome multiplication that depends on cellular microenvironment, immune response of the host and proliferative potential of the infected epithelium. |
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