Trafficking in human beings is a substantial component of the international criminal business. However, the economic instability of different regions and the inefficient prophylaxis of crimes stimulate human trafficking. The targeted criminal activity is based on illegal migration and on the occasion of illegal use of labour. These factors make it easier for criminals to manipulate people and earn fabulous income. Revenues from transnational organized crime as a result of trafficking in human beings are highly profitable, compared to the arms and drug trade, and sometimes even exceeding it. The international community has imposed strict bans on all forms of slavery, recognizing human trafficking and forced labour as crimes against humanity. Article 7 of the Rome Statute of the International Criminal Court assigns to the category of crimes against humanity enslavement, rape, sexual slavery, enforced prostitution, forced pregnancy, enforced sterilization or any other form of sexual violence of comparable gravity, if committed as part of a widespread or systematic attack directed against any civilian population. If we show that trafficking in human beings is a variety of the slave trade, and forced labour is a form of slavery, then it is natural to repress these phenomena, which are of greater danger to all humanity, which also affects human trafficking. However, precisely because of the brutal nature of the violation of human rights and freedoms, trafficking in human beings is put on the same scale as crimes against humanity. The study presented focuses on the treatment of evidence and circumstances to be proven in the process of criminal prosecution in cases of trafficking in human beings.