Globalization as a qualitative new phase of development of international system and world economy (rapid economic growth; global market of goods, services, capital) is one of the most discussed questions in contemporary world; it became very popular not only in international relations but also in historical, political, socio-economical, ecological and technical sciences. The XXI century is a period of global challenges and responses for human civilization. The role of global problems in the process of the formation of new way of thinking is very important, particularly in the context of intensification consequences of globalization in the world and Republic of Moldova is not exception. New political thinking stands for a process in which we ought to recognize each other humanity as we move to solve complex problems dealing with social and political life, economies and global relations. The article analyzes the changes in the political thinking and examines the impact of globalization on the internal development, national interest, and foreign policy. Now, when our country are in the transitional period (rebuilding the state, fostering democracy) which include such difficulties as attracting foreign investment, inflation, unemployment, influence of global process play special role for the future of its population both for a short-term and long-term perspectives. New way of thinking, based on the moral imperative, ideology of humanism and spiritual country is a real alternative to negative consequences of globalization. Contemporary issues present a greater challenge to the global interdependence system, and demand cooperation among societies and political actors around the world.