Effective light absorption spectra of endogenic porphyrins in soft biotissue
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SHONTYA, Viktor, ABRAMOVICH, Nicolai, BARUN, V., DICK, Serghei, SERYAKOV, Alexandr. Effective light absorption spectra of endogenic porphyrins in soft biotissue. In: E-Health and Bioengineering Conference: EHB 2015, Ed. 5, 19-21 noiembrie 2015, Iași. New Jersey, SUA: Institute of Electrical and Electronics Engineers Inc., 2016, Ediţia a 5-a, p. 0. ISBN 978-146737545-0. DOI: https://doi.org/10.1109/EHB.2015.7391435
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E-Health and Bioengineering Conference
Ediţia a 5-a, 2016
Conferința "5th IEEE International Conference on E-Health and Bioengineering"
5, Iași, Romania, 19-21 noiembrie 2015

Effective light absorption spectra of endogenic porphyrins in soft biotissue

DOI: https://doi.org/10.1109/EHB.2015.7391435

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Shontya Viktor1, Abramovich Nicolai2, Barun V.3, Dick Serghei2, Seryakov Alexandr1
 
1 Technical University of Moldova,
2 Belarusian State University,
3 Stepanov Institute of Physics, National Academy of Sciences of Belarus
 
Disponibil în IBN: 19 ianuarie 2023


Rezumat

Light action spectra for main skin chromophores are simulated. Endogenic porphyrins (Pp IX, Cp III, and Up III) are selected as target chromophores. They can produce singlet oxygen (SO) under tissue irradiation, which acts as a natural photosensitizer. The SO is toxic for, e.g., cancer cells. This process is known to be widely used in photodynamic therapy (PDT). It is shown by way of examples that skin irradiation by red light, where the porphyrins have local maxima of light absorption, can improve the generation of SO as compared with the irradiation at a wavelength corresponding to the absolute maximum of light absorption. We obtained that the said improvement of SO generation can be about 5 to 10 times at specific depths inside tissue and 2 to 12 times integrally for the whole dermis thickness. The presented results can provide new opportunities for the selection of the irradiation wavelengths under application of traditional PDT methods.

Cuvinte-cheie
endogenic porphyrins, light action spectra, radiative transfer equation, Singlet oxygen, soft biological tissue