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Articolul urmator |
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SM ISO690:2012 SHONTYA, Viktor, ABRAMOVICH, Nicolai, BARUN, V., DICK, Serghei, SERYAKOV, Alexandr. Effective light absorption spectra of endogenic porphyrins in soft biotissue. In: E-Health and Bioengineering Conference: EHB 2015, Ed. 5, 19-21 noiembrie 2015, Iași. New Jersey, SUA: Institute of Electrical and Electronics Engineers Inc., 2016, Ediţia a 5-a, p. 0. ISBN 978-146737545-0. DOI: https://doi.org/10.1109/EHB.2015.7391435 |
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E-Health and Bioengineering Conference Ediţia a 5-a, 2016 |
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Conferința "5th IEEE International Conference on E-Health and Bioengineering" 5, Iași, Romania, 19-21 noiembrie 2015 | |||||
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DOI: https://doi.org/10.1109/EHB.2015.7391435 | |||||
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Light action spectra for main skin chromophores are simulated. Endogenic porphyrins (Pp IX, Cp III, and Up III) are selected as target chromophores. They can produce singlet oxygen (SO) under tissue irradiation, which acts as a natural photosensitizer. The SO is toxic for, e.g., cancer cells. This process is known to be widely used in photodynamic therapy (PDT). It is shown by way of examples that skin irradiation by red light, where the porphyrins have local maxima of light absorption, can improve the generation of SO as compared with the irradiation at a wavelength corresponding to the absolute maximum of light absorption. We obtained that the said improvement of SO generation can be about 5 to 10 times at specific depths inside tissue and 2 to 12 times integrally for the whole dermis thickness. The presented results can provide new opportunities for the selection of the irradiation wavelengths under application of traditional PDT methods. |
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Cuvinte-cheie endogenic porphyrins, light action spectra, radiative transfer equation, Singlet oxygen, soft biological tissue |
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