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616.379-008.64:616.4 (2) |
Patologia sistemului digestiv. Tulburări ale tubului alimentar (1732) |
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SM ISO690:2012 EŞANU, Valeriu, EŞANU, Veronica, PÎRŢU, Lucia, RODOMAN, Iulia, VUDU, Lorina, PALII, Ina. Corelația dintre hemoglobina glicată și profilul lipidic seric în diabetul zaharat de tip 1 . In: Buletin de Perinatologie, 2022, nr. 1(93), pp. 123-128. ISSN 1810-5289. |
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Buletin de Perinatologie | ||||||
Numărul 1(93) / 2022 / ISSN 1810-5289 | ||||||
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CZU: 616.379-008.64:616.4 | ||||||
Pag. 123-128 | ||||||
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Background. Pediatric patients with type 1 diabetes (T1D) have an increased prevalence of dyslipidemia, which contributes to their high risk of cardiovascular diseases (CVDs). Aim. This study is an attempt to determine the correlation between hemoglobin A1c (HbA1c) and serum lipid profile in children with T1D. Material and methods. A total of 45 children with T1D (aged 10-18 years; gender M (25) / F (20); duration of T1D ≥ 5 years; absence of hypertension, insulin therapy) were included in this study. The sera were analyzed for HbA1c, total cholesterol (TC), triglycerides (TGs), high-density lipoprotein cholesterol (HDL-C), and low-density lipoprotein cholesterol (LDL-C). Dyslipidemia was defined according to the Third Report of the National Cholesterol Education Program. Diabetes was defined as per American Diabetes Association criteria. The correlation of HbA1c with individual lipid indexes was analyzed. The statistical analysis was done by SPSS statistical package version 20.0. Results. The mean age ± standard deviation of participants was 15.71 ± 2.40. There was a significant positive correlation between HbA1c, TC, TG, and LDL-C. The correlation between HbA1c and HDL-C was negative and was statistically nonsignificant. Patients with an HbA1c value greater than 7.0% had significantly higher values of cholesterol, LDL-C, and TG, compared with patients with an HbA1c value of up to 7.0%. Conclusions. HbA1c can also be used as a predictor of dyslipidemia and thus early diagnosis of dyslipidemia can be used as a preventive measure for the development of CVD in children with T1D. |
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Cuvinte-cheie type-1 diabetes mellitus, children, Lipid profile, сахарный диабет 1 типа, дети, липидный профиль |
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