The development of global entrepreneurship nowadays cannot even be imagined without the use of digital technologies, namely e-commerce techniques. E-commerce has managed to radically change the business strategies of enterprises and their development vision, giving them the opportunity to expand globally, easily conquering markets around the world. On the one hand, ecommerce has managed to infiltrate companies around the world, but on the other hand, the degree of use of these digital tools differs considerably in the regional profile, being influenced by multiple influencing factors. In this context, this article aims to examine the theoretical approaches of various scholars regarding electronic commerce and its role in the development of entrepreneurial activity, based on the analysis of statistical data that aims to argue the theoretical assertions. In order to argue the development trends of e-commerce, in this paper there are presented the analysis of the statistical data related to the dynamics of retail e-commerce sales worldwide and the dynamics of e-commerce as percentage of total retail sales worldwide, also examining their spatial distribution. As a particular case, this article examines the dynamics of the e-commerce revenue in the Republic of Moldova by category of goods, which argues that even in developing countries e-commerce is enjoying a fierce development. An important role in this article belongs to the examination of the main benefits of online shopping worldwide argued from the point of view of consumers and from the point of view of economic agents.