Preparation of composite based on caffeic acid and fumed silica and evaluation of its antioxidant and antimicrobial properties
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STAVINSKAYA, Oksana, LAGUTA, Iryna, KUZEMA, Pavlo, SKOROCHOD, Iryna, ROY, Alla, KURDISH, Ivan. Preparation of composite based on caffeic acid and fumed silica and evaluation of its antioxidant and antimicrobial properties. In: Chemistry Journal of Moldova, 2022, nr. 2(17), pp. 43-49. ISSN 1857-1727. DOI: https://doi.org/10.19261/cjm.2022.984
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Chemistry Journal of Moldova
Numărul 2(17) / 2022 / ISSN 1857-1727 /ISSNe 2345-1688

Preparation of composite based on caffeic acid and fumed silica and evaluation of its antioxidant and antimicrobial properties

DOI: https://doi.org/10.19261/cjm.2022.984
CZU: [547.587.52+544.723]:54.05

Pag. 43-49

Stavinskaya Oksana1, Laguta Iryna1, Kuzema Pavlo1, Skorochod Iryna2, Roy Alla2, Kurdish Ivan2
 
1 Chuiko Institute of Surface Chemistry, National Academy of Science of Ukraine,
2 Zabolotny Institute of Microbiology and Virology, National Academy of Science of Ukraine
 
Disponibil în IBN: 29 decembrie 2022


Rezumat

The aim of this work was the preparation of a composite comprising caffeic acid (CA) and fumed silica (A300), and comparison of antioxidant and antimicrobial properties of CA in solution and in composite. The CA+A300 composite with CA content of about 25 mg/g was obtained using the sorptive modification of silica with CA solution under fluidized bed conditions. Antioxidant properties of the CA solution and the CA+A300 composite were studied using DPPH• and Folin-Ciocalteu assays, in addition OH• and NO• scavenging activity and antimicrobial properties against Staphylococcus aureus 209 strain were estimated. The results have shown that CA is very effective in the reaction with DPPH• radicals and that the inclusion of CA in the composite results in the slowing down of this reaction. The CA solution and the CA+A300 composite had a similar activity as NO• radicals’ scavengers and as antimicrobial agents, whereas the CA solution was more effective in inhibition of OH• radicals. It has been assumed that the difference in activity between the CA+A300 composite and the CA solution may be due to the gradual release of CA from the composite into reaction mixtures and by the increase in this release as CA is consumed in the reactions.

Cuvinte-cheie
caffeic acid, Fumed silica, composite, antioxidant, radical scavenger, Antimicrobial activity