|Conţinutul numărului revistei|
| SM ISO690:2012|
ROTARU, V. Producerea citokinelor la copii cu malformaţii nefrourinare şi infecţii ale tractului urinar . In: Buletin de Perinatologie. 2010, nr. 4(48), pp. 37-40. ISSN 1810-5289.
|Buletin de Perinatologie|
|Numărul 4(48) / 2010 / ISSN 1810-5289|
Background: Recent research results indicate that most of the pathophysiologic consequences of the bacterial infection are mediated by a complex interplay of proinflammatory cytokines triggered by the presence of microbial agents.
Material and methods. Children enrolled in our study were examined according to the degree of anatomical and functional disorders of kidneys and urinary tract. Accordingly, children were divided into two groups: 23 children with urinary tract infection (UTI) without impaired urodynamics and 24 children with UTI and diagnosed urodynamics disorder (16 of them with VUR I-II degree and 8 children with VUR III-IV degree. The control group included 20 children under one year of age with no episode of UTI or other infections, considered practically healthy.
Rezults: Correlation analysis of the urine concentration of pro-and anti-inflammatory cytokines in children with UTI did not reveal significant differences between the studied groups, which demonstrate that at early stages inflammatory processes have similar pathways and evolution.
However analysis of the cytokines level in children with urodynamics disorders revealed a direct correlation of the interleukin 1β concentration, IL- 6 and TNFα in the urine with the degree of structural and functional changes of kidneys. Thus the maximum level of urine cytokines concentration was found in children with vesicoureteral reflux (VUR).
Conclusions: In the first year of life the presence of a urinary tract infection in children determines changes of the inflammatory mediators and fibrogenesis process through the increased production of tumor necrosis factor-α, interleukin 1β (IL-1β) and interleukin 6 (Il-6), which elevated levels are found in urine.