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226 8 |
Ultima descărcare din IBN: 2023-11-17 15:08 |
SM ISO690:2012 MORAR, Ana, CAZACU, Maria, GANDACOV, Vladilena, MAZUR, Ecaterina, UNCU, Livia. Stability of the solution in the spectrophotometric determination of combined antimycotic eardrops. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 482. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | |||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | |||||
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Pag. 482-482 | |||||
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Background. The UV-VIS spectrophotometric method remains one of the most common, accessible methods applied in the analysis, and quality control of drugs, used both as a qualitative and quantitative method for determining the concentration of a substance in a solution. Objective of the study. Study of the solution stability in spectrophotometric determinations of combined antimycotic eardrops with econazole nitrate and ciprofloxacin hydrochloride. Material and Methods. Three experimental series of ear drops prepared in the laboratory; Agilent Technologies 8453 spectrophotometer, equipped with 1 cm thick cuvettes; thermostat; analytical standards of econazole nitrate and ciprofloxacin hydrochloride (Sigma Aldrich), solvent methyl alcohol (Sigma Aldrich). Results. Analysis of standard and sample solutions was performed immediately after preparation and after 24, 48 and 72 hours at 25, 30 and 40°C. Absorbance was assessed in triplicate; analyte concentrations in the samples (relative to a freshly prepared reference solution) and % SD were calculated. Samples were stable at room temperature for 72 hours. With increasing temperature, the analyte concentration in the sample gradually decreased (to 30°C after 48 days and to 40°C after 24 days). The acceptance criterion is: RSD ≤ 2% (1.37 for ciprofloxacin hydrochloride and 0.71 for econazole nitrate). Conclusions. The technique developed for the spectrophotometric determinations ensures the stability of the sample solutions within the acceptance rang |
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Cuvinte-cheie stability, spectrophotometry, combined eardrops, stabilitate, spectrofotometrie, picături auriculare combinate |
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