Objective. To evidentiate the importance of routine foetal morphology from 12-14 weeks and 20-24 weeks of amenorrhea, in prenatal diagnosis of cerebral-cranial malformation in order to establish obstetrical attitude. Material and method. During routine foetal ultrasound were examined cerebrocranial structures beginning with 12-14 weeks of amenorrhea. In some cases prenatal genetic exams were performed or genetic exam in newborns. Cases with severe cranial-cerebral malformations or associated with severe extrecerebral malformations, benefits of therapeutic abortion. In those situations or in neonatal death necroptic exams were done. Results. In period 01.01.1999-31.03.2008 were identified 51 cases with cerebral malformations: 12 cases with anencephaly (14-31 w.), 20 cases with holoprosencephaly (14-41 w), 8 cases with corpus callous agenesis (24-37 w), 2 cases with acranie (14-15 w), 3 cases with encephalocel (22-26 w) and 6 cases with hydrocephaly (18-37w). 24 cases benefit of therapeutic abortion. 27 pregnant women gave birth prematurely and at term. Neonatal death has been recorded in 19 cases. Conclusion. Routine foetal morphology performed at 12-14w. and at 21-24 w. could reveal the possibility of prenatal diagnosis of cerebral malformations and contribute to decrease of perinatal mortality and neonatal and infant morbidity.