Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
141 1 |
Ultima descărcare din IBN: 2023-05-13 11:25 |
Căutarea după subiecte similare conform CZU |
616.24-002.5-07-08 (11) |
Patologia sistemului respirator. Tulburări ale organelor de respiraţie (757) |
SM ISO690:2012 ADIYERI KUNNUMBRATH, Anjitha. Impact of microbiological nonconfirmation of M. tuberculosis infection on treatment otucome in adults with pulmonary tuberculosis. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 244. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.24-002.5-07-08 | ||||||
Pag. 244-244 | ||||||
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Rezumat | ||||||
Background. Worldwide, about one third of all tuberculosis (TB) cases miss microbiological confirmation. In these patients, TB diagnosis relies on clinical and imaging criteria. The potential impact of microbiological non-confirmation on TB treatment outcome needs to be assessed. Objective of the study. To compare treatment outcome in TB patients without microbiological confirmation (TBWM) with those in microbiologically proven TB (TBPM) in a high incidence MDR-TB setting. Material and Methods. We performed a retrospective cohort study to compare treatment outcome in patients with TBWM and those with TBPM registered in the Tuberculosis Monitoring and Evaluation System in the Republic of Moldova during 2017. We excluded pediatric and extrapulmonary TB patients as well those who did not have a complete set of microbiological tests (microscopy, Xpert MTB/Rif, culture) or who did not have registered outcome. Results. After excluding ineligible patients, 2565 TB cases were included into the final analysis, inclusively 891-TBFM and 1674 - TBCM. A higher mortality rate was observed in TBPM patients compared to TBWM (6.4% vs. 10.3%, p = 0.0008). At the same time, there was a higher number of TBFM patients in whom the diagnosis of TB was excluded after initiation of the TB treatment (5% vs. 1.1%, p < 0.0001). In the analyzed groups, the differences in treatment success and failure rates were statistically insignificant. Conclusion. Treatment outcome in TBWM is not inferior to those in TBCM, these data are different of those reported from areas with a low incidence of MDR TB. |
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Cuvinte-cheie TB, clinical and imaging diagnosis, empirical treatment, TB, diagnostic clinico-imagistic, tratament empiric |
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