Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
206 1 |
Ultima descărcare din IBN: 2023-02-11 12:00 |
Căutarea după subiecte similare conform CZU |
616.98:578.828HIV-036-07-085 (1) |
Boli transmisibile. Boli infecţionase şi contagioase, stări febrile (585) |
Virologie (442) |
SM ISO690:2012 MICȘANSCHI, Pavel, HOLBAN, Tiberiu, BÎSTRIȚCHI, Victoria, NAGÎŢ, Angela, GHIȚU, Elena. Evaluation of first line antiretroviral treatment in HIV infected patients and their subsequent therapeutic conduct. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 117. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | ||||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | ||||||
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CZU: 616.98:578.828HIV-036-07-085 | ||||||
Pag. 117-117 | ||||||
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Background. ART has been shown to be effective in controlling HIV infection, which has significantly reduced the morbidity and mortality of people living with HIV+. Objective. Early detection of HIV+ patients who did not presented a sustained virological response to first-line ART. Material and methods. An analytical, observational cohort study (retrospective, prospective) was performed on 229 with HIV in ART in 2011-2021: I group-120 patients without therapeutic failure and II group-109 patients with ART failure of I line, monitored virological, immunological, and clinical. Results. Second line ART was initiated in 101 patients with therapeutic failure, in 2/3 of cases HIV ARN> 100,000 copies/ ml and an increased epidemiological risk were detected. At 5 months after initiation of II line ART - 93 patients had HIV RNA <25 copies/ml, 8 with delayed virosological response. Average of CD4 – 185.01 cell/μL: 87 patients with CD4 <350, out of whom 65 - CD4 <200 and 32 - CD4 <50. Patients with CD4 <50 cells have an increased risk of opportunistic infections and death. The duration from the onset of I line ART to the onset of virological failure and the onset of II line ART was different, average being 4 years (1-10 years). Conclusion. The necessity for early detection of I line ART failure has been demonstrated in order to prevent advanced immunosuppression and increased viral load, as well as to improve patients’ quality of life and achieve a sustained virus response to second-line ART. However, if the failure of ART occurs in a relatively short period of time, reduced adherence to ART has an inevitable role. How to improve adherence is important, so that the next ART scheme is more sustainable. |
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Cuvinte-cheie ART-antiretroviral treatment, HIV-human immunodeficiency virus, TARV-tratament antiretroviral, HIV- virus imunodeficienței umane |
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