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similare conform CZU
|Stomatologie. Cavitatea bucală. Gură. Boli ale gurii şi dinţilor (431)|
| SM ISO690:2012|
STRATAN, Valentina; POPA, Cristina; SÎTNIC, Victor; ŢUŢUIANU, Valeri; CEBOTARI, Diana; COJOCARI, Corneliu. Periodontal pathogenic analysis in the oral microbioma at patients with head and neck scuamous cell carcinoma. In: Revista de Ştiinţe ale Sănătăţii din Moldova. 2022, nr. 3 An.1(29), p. 31. ISSN 2345-1467.
|Revista de Ştiinţe ale Sănătăţii din Moldova|
|Numărul 3 An.1(29) / 2022 / ISSN 2345-1467|
Background. Research on the relationship between the human microbiome and malignant tumors has received particular interest in recent years. Regarding the oral microbiota, there are different types of bacteria that are associated with oncogenesis of head and neck squamous cell carcinoma (HNSCC). Objective of the study. The purpose of our study was to determine the concentration of periodontal pathogens in the oral microbiome in patients with HNSCC. Material and methods. 26 saliva and oral buffer samples were analyzed from patients with HNSCC by quantitative PCR method. A comprehensive quantitative research kit „Dentoscreen” (Litech) was used, which allows the identification of the DNA of 7 periodontal pathogens: Porphyromonas endodontalis, Porphyromonas gingivalis, Aggregatibacter actinomycetemcomitans, Treponema denticola, Fusobacterium nucella. Results. Show that F. nucleatum exceeds the norm in 20 samples and T. forsythia in 18. F. nucleatum is found in high concentrations in most smokers and only in one patient in the “Non-smokers” category. Samples with abnormal concentrations of A. actinomycetemcomitans show high concentrations for most species. In addition, the integration with clinical data indicates the pathological presence of P. endodontalis at all patients with laryngeal carcinoma and approx. in 30% of patients with lip and oropharynx carcinoma. Conclusion. Of all the 7 species studied, F. nucleatum and T. forsythia have pathological concentrations in most samples.
oral microbiome, periodontal pathogenic, squamous cell carcinoma of the head and neck,
microbiom oral, agenților patogeni parodontali, carcinom cu celule scuamoase cap-gât