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SM ISO690:2012 ŞINCARENCO, Irina, LACUSTA, Victor, BORDENIUC, Gheorghe, GÎLEA, Angela, CEREŞ, Victoria. The frequency and expression of Frank’s earlobe sign in patients with COVID-19. In: Revista de Ştiinţe ale Sănătăţii din Moldova, 2022, nr. 3 An.1(29), p. 295. ISSN 2345-1467. |
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Revista de Ştiinţe ale Sănătăţii din Moldova | |||||
Numărul 3 An.1(29) / 2022 / ISSN 2345-1467 | |||||
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CZU: 616.9:578.834.1:616.1/.2-036 | |||||
Pag. 295-295 | |||||
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Background. During the COVID-19 pandemic, numerous clinical signs, especially cutaneous were investigated regarding their associations with the infection. An auricular COVID-19 marker was previously described (edema of the superior tragus, supratragal notch, and ascending helix). The Frank’s Sign (FS) is an established auricular marker of cardiopulmonary disease and may be a potential COVID-19 marker, due to the severe impact of the disease on the cardiopulmonary system. Objective of the study. Evaluating the frequency and expression of Frank’s sign in patients with COVID-19, in comparison with healthy controls. Material and Methods. There were enrolled 60 individuals (aged 35-60 years), of which: 40 COVID-19 patients (20 – severe form, post-ventilator therapy; 20 – mild form, outpatient care) and 20 healthy controls (negative PCR, no COVID-19 history). FS was identified by an experimented investigator, and special criteria for FS expression were developed, based on the quantitative features (length, indentation degree). The activity of cardiovascular system was evaluated via an autonomic index (MI – myocardial index) of vascular coronary system regulation (ECG dispersion mapping). Results. FS is 2 times more frequent in severe than in mild COVID-19 and 3 times more common when compared to controls. In severe COVID-19, the FS intensity is 5 times higher than in mild form and 10 times higher than controls. There were observed trends of higher FS frequency (p < 0,05), FS intensity (p < 0,001) and MI values (p < 0,001) in severe vs. mild COVID-19. Conclusion. Our preliminary results showed a correlation of the presence and expression of the diagonal ear lobe crease (Frank’s sign) with the clinical variants of the disease. |
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Cuvinte-cheie COVID-19, Frank’s sign, ECG dispersion mapping, COVID-19, semnul Frank, ECG dispersion mapping |
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