Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
1073 12 |
Ultima descărcare din IBN: 2023-10-05 16:29 |
SM ISO690:2012 COREŢCHI, Ianoş. Acţiunea asocierii profeturului cu hexametoniu asupra microcirculaţiei. In: Curierul Medical, 2012, nr. 4(328), pp. 45-50. ISSN 1875-0666. |
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Curierul Medical | ||||||
Numărul 4(328) / 2012 / ISSN 1875-0666 | ||||||
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Pag. 45-50 | ||||||
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This study looks at a new derivative of Alkyl Isothiourea, Profetur, under different routes of administration (intravenous and local). The study examines the effects of Profetur on microcirculation in the rats mesoappendix under normal conditions and in combinatiob with the pharmacological denervation of blood vessels. When administered intravenously to rats at the dose of 20 mg/kg and, when applied at a dilution of 1:500 solutions on the surface of the mesoappendix Profetur narrows metarterioles, arterioles, reduces the number of functional capillaries and increases blood flow velocity in the arterioles. Intravenous administration of the Profetur in the same dose and when applied topically at a dilution of 1:5000 in combination with
hexamethonium, normalizes microcirculation, constricts arterioles and metarterioles to their initial level, and speeds up bloodflow. The effects of a local
application of Profetur at a dilution of 1:5000 in combination with hexamethonium are similar to those when using the substance at a dilution of 1:500 in normal conditions. This suggests that the pharmacological denervation of blood vessels increases sensitivity to Profetur. |
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Cuvinte-cheie profetur, blood pressure, microcirculation, hexamethonium, pharmacological denervation |
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