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SM ISO690:2012 CIOBANU, Lucia, COBEŢ, Valeriu, CIOBANU, Nicolae, POPOVICI, Mihail. Produsele finale ale glicării şi elasticitatea arterelor periferice în insuficienţa cardiacă. In: Curierul Medical, 2012, nr. 4(328), pp. 31-36. ISSN 1875-0666. |
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Curierul Medical | |||||
Numărul 4(328) / 2012 / ISSN 1875-0666 | |||||
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Pag. 31-36 | |||||
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Advanced glycation and products (AGEs) are modifications of proteins or lipids that become nonenzymatically glycated and oxidized after contact with mono-sugars. Bounding to specific cell receptors they lead to cross-link formation basically of the large matrix proteins such as collagen and elastin resulting in increased stiffness of the vasculature. By this reason we evaluated the AGEs circulating levels and artery elasticity indices in heart failure due to diastolic or systolic dysfunction. In hypertensive patients with diastolic dysfunction AGEs level elevated 2.5 times while elasticity value of large and smooth arteries decreased by 54 and 46% respectively. Systolic dysfunction was associated with AGEs rising 2.9 times and smooths elasticity index diminution by almost 30%. Hence, the AGEs can be vied as a predictor of vascular stiffening and remedies of glycation inhibition may be useful in heart
failure treatment. |
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Cuvinte-cheie advanced glycation products, artery elasticity, heart failure |
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