Antibacterial and Antifungal Silver Nanoparticles with Tunable Size Embedded in Various Cellulose-Based Matrices
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BILIUTA, Gabriela, BOSTĂNARU, Andra-Cristina, MAREȘ, Mihai, PAVLOV-ENESCU, Carla, NĂSTASĂ, Valentin, BURDUNIUC (POPA), Olga, COSERI, Sergiu. Antibacterial and Antifungal Silver Nanoparticles with Tunable Size Embedded in Various Cellulose-Based Matrices. In: Molecules (Basel, Switzerland), 2022, vol. 27, pp. 1-13. ISSN -. DOI: https://doi.org/10.3390/molecules27196680
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Molecules (Basel, Switzerland)
Volumul 27 / 2022 / ISSN - /ISSNe 1420-3049

Antibacterial and Antifungal Silver Nanoparticles with Tunable Size Embedded in Various Cellulose-Based Matrices

DOI: https://doi.org/10.3390/molecules27196680

Pag. 1-13

Biliuta Gabriela1, Bostănaru Andra-Cristina2, Mareș Mihai2, Pavlov-Enescu Carla2, Năstasă Valentin2, Burduniuc (Popa) Olga34, Coseri Sergiu1
 
1 “Petru Poni” Institute of Macromolecular Chemistry,
2 Universitatea de Ştiinţe Agricole şi Medicină Veterinară „Ion Ionescu de la Brad”, Iaşi,
3 ”Nicolae Testemițanu” State University of Medicine and Pharmacy,
4 National Agency for Public Health
 
Disponibil în IBN: 30 octombrie 2022


Rezumat

 The aim of this study was to synthesize silver nanoparticles (AgNPs) using cellulose derivatives and to evaluate their antimicrobial potential. As effective reducing and stabilizing agents for AgNPs, cellulose derivatives, such as hydroxypropyl cellulose (HPC), methylcellulose (MC), ethylcellulose (EC), and cellulose acetate (CA), were used. Their ability to reduce silver ions as well as the size of the resulting AgNPs were compared. The formation and stability of the reduced AgNPs in the solution were monitored using UV-Vis analysis. The size, morphology, and charge of the AgNPs were evaluated. We found that, when using cellulosic derivatives, AgNPs with sizes ranging from 17 to 89 nm and different stabilities were obtained. The parameters, such as size and ζ potential indicate the stability of AgNPs, with AgNPs-CA and AgNPs-HPC being considered more stable than AgNPs-EC and AgNPs-MC since they show higher ζ potential values. In addition, the AgNPs showed antimicrobial activity against all reference strains and clinical isolates. MIC values between 0.0312 and 0.125 mM had a bactericidal effect on both Gram-positive and Gram-negative bacteria. The fungicidal effect was obtained at a MIC value of 0.125 mM. These results may provide rational support in the design of medical gauze products, including gauze pads, rolls, and sponges. 

Cuvinte-cheie
AgNPs, Antimicrobial activity, cellulose acetate, cellulose derivatives, ethylcellulose, hydroxypropyl cellulose, methylcellulose