The Global Plan of Action (GPA) for conservation and sustainable utilization of Plant Genetic Resources for Food and Agriculture (PGRFA) is an initiative of Food and Agricul-ture Organization (FAO), adopted during the Fourth International Technical Conference on Plant Genetic Resources, which held in Leipzig, Germany, from 17 to 23 June 1996. The Conference also adopted the Leipzig Declaration, which focuses attention on the importance of plant genetic resources for world food security, and commits countries to implementing this Plan. It contains the priority actions identified, at local, national, regional and internati-onal levels. It provides an integrated framework for systematic, rational, balanced and equi-table cooperation.The GPA is a framework of activities encompassing development of in situ conservation of PGRFA, sustaining existing collections, enhancing utilization and increasing capacity of countries regarding education, public awareness and training on these aspects. FAO has developed a monitoring process of implementation of GPA in different countries through a mechanism called National Information Sharing Mechanism (NISM) for monito-ring the implementation of GPA. It is an information network for monitoring activities car-ried out to implement the Global Plan of Action (GPA) on Plant Genetic Resources for Food and Agriculture (PGRFA) NISM has been developed by FAO in partnership with Bioversity International to help monitor in-country progress in relation to the Global Plan Action. NISM is a partnership among stakeholders that contribute to the conservation and sustainable use of plant genetic resources for food and agriculture. The application of the new monitoring approach led to the establishment of 65 National Information Sharing Mechanisms (NISM), which provide comprehensive information on all of the 20 priority activity areas of the Glo-bal Plan of Action. As part of this monitoring effort, key national PGRFA stakeholders have established National Information Sharing Mechanisms (NISM), and published detailed infor-mation on the state of conservation and sustainable use of PGRFA in their respective coun-tries, through web portals and databases. NISM data, which includes, inter alia, information on more than 24.000 publications, 18.000 projects, 61.000 cultivars and 18.000 stakeholders, can also be accessed through the World Information Sharing Mechanism on PGRFA, and automatically feed the WIEWS database on ex situ collections. In all countries that have established NISMs, the mechanism contributed important information to and facilitated the preparation of the Country Report. Data provided by NISMs have also used for the analysis of regional and global trends, for quality assurance and for the identification of priorities and needs in the sector of plant genetic resources for food and agriculture [1]. The experience of the Republic of Moldova in implementation of this mechanism and its outcome is discuss in this article.