Lung function dereglation in patients with liver cirrhosis of viral etiology B and D
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TARAN, Natalia, CHIRVAS, Elena, LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana, GHELIMICI, Tatiana. Lung function dereglation in patients with liver cirrhosis of viral etiology B and D. In: Journal of Gastrointestinal and Liver Diseases, 2019, nr. S2(28), pp. 67-68. ISSN 1841-8724.
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Journal of Gastrointestinal and Liver Diseases
Numărul S2(28) / 2019 / ISSN 1841-8724 /ISSNe 1842-1121

Lung function dereglation in patients with liver cirrhosis of viral etiology B and D


Pag. 67-68

Taran Natalia, Chirvas Elena, Lupaşco Iulianna, Dumbrava Vlada-Tatiana, Ghelimici Tatiana
 
”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 24 august 2022


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Objectives. Assessment of pulmonary function in patients with liver cirrhosis of viral etiology B and D. Pulmonary dysfunction is common feature in patients with long standing liver affection and 70% of patients with liver cirrhosis, but there is lack of existing data about viral infection influence on its development. Materials and methods. 41 patients with viral liver cirrhosis LC D and 10 patients with viral LC B were included in the study. Patients with LC D: 5 patients - Child-Pugh A, 14 patients - Child-Pugh B stage, 22 patients - Child-Pugh C stage. Patients with LC B: 3 patients were Child-Pugh A, 4 patients - Child-Pugh B, 3 patients - Child-Pugh C. Half of the patients with viral cirrhosis B were HBsAg-positive. All patients underwent spirometry with FVC, FEV1, FEV1 / FVC, FEF25-75 assessment. Results. Among patients with LC D in 48.78% of cases (20 pts), changes in pulmonary function indicators were found in 15% of patients with Child-Pugh Astage, 40% of patients Child Pugh B, 45% - Child-Pugh C. Among patients with LC D with modified pulmonary function indicators, (FVC <90%) was assessed in 16 patients (80%), of which 12 (60%) were restricted to 4 p. (20%) obstructive component (mixed pattern): FVC < 90% and FEV1 ≤ 80% - 1 p. (5%); FVC < 90%, FEV1 ≤ 80% and FEF25-75 ≤ 66% at 3 pts (15%). The severity of hepatic pathology at 12 pts (isolated restrictive pattern) was as follows: Child-Pugh A - 1 p. (8.33%), Child Pugh B - 5 p. (41.66%), Child Pugh C - 6 pts (50%), with statistically significant differences between the Child-Pugh B and C groups (p<0.05) according to the non-parametric U Mann-Whitney criterion. At the same time, in all patients with LC B, regardless of ChildPugh stage, were determined normal values of spirographic values. Taking into account the preliminary data from our study, predominantly pulmonary function impairment was observed in patients with liver cirrhosis D in Child-Pugh B and C stages versus patients with LC B without changes in pulmonary function indicators, regardless of the liver disease stage (p<0.005). Conclusions. Changes in pulmonary ventilation have been observed in patients with liver viral D infection versus hepatic viral B infection, more evident in the advanced stages of the disease. To confirm the hypothesis of impaired pulmonary function by viral D infection in liver cirrhosis, it is necessary to continue the study.

Cuvinte-cheie
liver cirrhosis, lung function indicators, Child-Pugh stage