Bacterial translocation in non-ascitic cirrhotic patients with splenomegaly, severe hypersplenism The aim of this study was to evaluate the frequency and clinical significance of microbiologically confirmed bacterial translocation to the mesenteric lymph node in cirrhotic patients with splenomegaly, severe hypersplenism. A series of 21 consecutive cirrhotic patients with splenomegaly and severe hypersplenism were treated using the splenectomy, transabdominal azygo-portal disconnection and 19 patients with gallbladder stone were treated by classic colecistectomy, within which were excised and microbiologically investigated the mesenteric lymph nodes. The results suggest that the bacterial translocation in non-ascitic cirrhotic patients with splenomegaly and severe hypersplenism was 23,8 % cases comparative with 5,3% in colestomizated patients. Possible the immunosuppression determined by progressive hypersplenism present one the factor that predispose to bacterial translocation in this patients.

Obiectivul studiului dat a constituit estimarea frecvenţei şi semnificaţiei clinice a transclocării bacteriene în nodulii limfatici mezenterici la bolnavii cirotici cu splenomegalie şi hiperseplenism sever. Un lot consecutiv de 21 pacienţi cirotici cu splenomegalie şi hipersplenism sever au fost trataţi prin splenectomie cu deconectare azygo-portală cît şi 19 bolnavi cu litiază biliară în cadrul căreea au fost excizaţi şi supuşi cercetărilor bacteriologice nodulii limfatici mesenterici. Rezultatele sugestă, că rata translocării bacteriene la pacientul cirotic non-ascitic cu splenomegalie şi hipersplenism sever a constituit 23,8 % cazuri comparativ cu 5,3% la bolnavii colecistectomizaţi. Probabil imunosupresia condiţionată de hipersplenismul progresant reprezintă un factor ce predispune către translocarea bacteriană la aceşti pacienţi.