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3009 96 |
Ultima descărcare din IBN: 2024-02-12 19:19 |
SM ISO690:2012 PELTEC, Angela, DUMBRAVA, Vlada-Tatiana, BODRUG, Roman, TĂNASE, Raisa, ŢURCAN, Svetlana, BÂRCA, Silvia. Terapia secvenţialâ pentru eradicarea infecţiei helicobacter pylori ca prima linie de tratament. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 3(12), pp. 229-233. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 3(12) / 2011 / ISSN 1857-1719 | ||||||
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The sequential therapy for eradication of helicobacter pylori infection as a first–line therapy
Background: Standard proton-pump inhibitor– based therapy for Helicobacter pylori
infection fails in up to one quarter of patients. Sequential therapy may be more efficacious.
Purpose: To compare sequential therapy with standard triple therapy for H. pylori infection.
Materials and methods: This is a prospective, open-label, single-centre study. The study
involved 42 consecutive patients with peptic ulcer. All patients were randomly assigned into 2
study groups. The first group of patients were administered a sequential treatment: pantoprazole
40 mg b.d and amoxicilline 1000mg b.d for the first 5 days and pantoprazole 40 mg b. d,
secnidosole 500 mg b. d , and clarithromycine 500mg b. d for the remaining 5 days. The second
group of patients was administered pantoprazole 40 mg b. d, amoxicilline 1000mg b. d, and
clarithromycine 500 mg b. d (PAC) for 10 days. Eradication was defined as the absence HP as
assessed with the fecal test (antigens Hp) 4 weeks after the end of the antimicrobial therapy.
Results: The eradication rate in the sequential group was 64% for the ITT analysis and 92% for
the PP analysis; the eradication rate of the PAC group was 60 % for PP and 68% - for ITT
analysis. There was a statistically significant difference between the eradication rates of the
groups for both PP and ITT analysis. There was no statistically significant difference in the
adverse effects encountered in both groups (11,8% versus 12% P > 0.05). Conclusion: These
results suggest that a 10-day sequential eradication regimen is more effective as a first-line
therapy for HP eradication. |
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