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Ultima descărcare din IBN: 2024-02-20 11:27 |
SM ISO690:2012 FATHIBAROUD, AllaaM., DIUG, Octavian, DIUG, Eugen. Optimizarea formulării comprimatelor orodispersabile cu maleat de clorfeniramină. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 1(12), pp. 393-398. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | ||||||
Numărul 1(12) / 2011 / ISSN 1857-1719 | ||||||
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Pag. 393-398 | ||||||
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Rezumat | ||||||
Optimization of the formulation orodispersable tablets of chlorpheniramine maleate
The purpose of this research was to develop mouth dissolve tablets of Chlorpheniramine
maleate. Tablets were prepared by direct compression. The tablets were evaluated for
disintegration time and hardness test. In the investigation, a 32 full factorial design was used to
investigate the joint influence of 2 formulation variables: amount of Croscarmellose sodium and
Lactose. The results of multiple linear regression analysis revealed that for obtaining of a rapidly
disintegration dosage form, tablets should be prepared using an optimum concentration of
Lactose and higher percentage of Croscarmellose sodium. |
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Cuvinte-cheie maleat de clorfeniramină, croscarmeloză sodică, comprimate orodispersabile, lactoză, design factorial |
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