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SM ISO690:2012 STRATU, Ecaterina, GHICAVÂI, Victor, COREŢCHI, Ianoş. Acţiunea musculotropă comparativă a profeturului cu alţi compuşi izotioureici pe segmente de intestin izolat de şobolan
. In: Analele Ştiinţifice ale USMF „N. Testemiţanu”, 2011, nr. 1(12), pp. 313-317. ISSN 1857-1719. |
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Analele Ştiinţifice ale USMF „N. Testemiţanu” | |||||
Numărul 1(12) / 2011 / ISSN 1857-1719 | |||||
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Pag. 313-317 | |||||
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The comparing musculotropic action of profetur with other iyothyoureic
compounds on the rats intestine isolate segments
As the result of pharmacology screening, profetur compounds on the smooth muscles of
isolated parts of intestine have showed the increase of contractile activity. Contractile activity
increases during administration of a higher concentration from l x 10-2M to l x l0-4M. The dose -
effect curve goes down when the saturation of occupeid receptors is at a concentration of 1x10-4M.
At the introduction of profetur compounds the contractile activity of bowels does not change at
advance administration of atropine at Зх10-6 М concentration pirensepine at 3xl0-6M concetration.
Profetur and izoturon are not the concurrent agents of histaminoreceptors and
cholinoreceptors. |
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