In this material, we want to assess the impact that anthropization has as a significant factor in the spread of Impatiens balsamina L. and Reynoutria japonica Houtt species. In our research, we took into account the already mapped and known populations of these two non-native species that have accentuated invasive-aggressive tendencies where anthropogenic, edaphic, ecological, and climatic factors allow them. At the same time, in our research, we have shown that the trend of aggressive-invasive spread is emphasized by the major climate changes that are taking place in the last decade. The spread of these two species has become problematic in the last decade because, due to environmental factors, it has become unrestrained and is about to become uncontrollable in certain areas and for some points of interest in the studied river basin. Both species spread rapidly on disturbed and marginal lands. Their aggressive spread leads to the elimination of valuable meadow habitats, the reduction of biodiversity, and the appearance of chemical changes in the soil. Based on the current population spread, we used Inverse Distance Weighting (IDW) interpolation which estimates unknown values by specifying search distance, closest points, power setting, and barriers. This results in a map of the species' potential distribution within the basin.