Recently, along with traditional medicines for the treatment of burns, the possibility of using physical methods that can affect various stages in the pathogenesis of the wound process is of great interest [1]. The use of low-intensity currents without external power supplies, which are generated directly by biological objects, deserves special attention [2]. Despite the fact that experimental research in this direction began only in the middle of the twentieth century, convincing positive results were obtained for the effectiveness of their use, which contributed to its rapid introduction to practical medicine in various fields [3]. Electroreflexology and electrophoresis of drugs were the forms implemented. Further analysis of the results of clinical application of electroreflexology allowed to identify a new direction in medicine - biogalvanization, which on the basis of cutaneous and visceral interactions allows to identify, correct and promote normalization of autonomic functional and energy balance, while ensuring bioenergetic homeostasis. A significant contribution to the study of this area was made by prof. Makats V.G. et al., who were particularly interested in application of this method in combustiology, especially taking into account the integral function of the skin [4]. It was found that direct galvanic current is an active biological stimulator, which is realized with the participation of humoral, neuroreflectory and immune mechanisms [5]. In addition, this current is able to promote the penetration of drugs into the body. Such directional electrophoresis allows to provide high concentrations of active substances in the wound, enhancing their pharmacological effect. Moreover, the ability of low-intensity currents to inhibit the growth and reproduction of microorganisms, as well as increase their sensitivity to antimicrobial agents, has been established [6]. The use of low-intensity currents without external power supplies in combination with existing traditional treatment of patients with wounds, as wound dressings, remains promising. The developed technology of activation of lyophilized pig skin xenografts by biogalvanic current for closing burn wounds at early surgical necrectomies allowed to improve efficiency of their application with a possibility of longer presence on a wound [7]. So far, positive results of in vitro experimental studies have been obtained to enhance the antimicrobial properties of synthetic composite modified materials based on poly(2-hydroxyethyl methacrylate) with the addition of drugs [8]. Thus, the use of low-intensity currents without external power supplies in medicine and in the treatment of patients with burns in particular, has undeniable effectiveness and requires wider implementation in clinical practice. The lack of information on a number of mechanisms of action of such currents on biological objects unequivocally indicates the need for further research in this direction.