Aim and methods: Recent studies evidenced that various ground and surface water sources contain antibiotics residues. These pollutants represent potential threats to the ecosystem due to bacterial resistance development even at low concentrations. Many studies were focused on the utilization of photocatalysis for water treatment due to the obtained successful results. TiO2 is one of the best material used for these applications. The aim of this study was to obtain new photocatalysts based on modified TiO2 in order to be used in degradation of different antibiotics from water. The effects of dopant (Au, Ag, Fe, C, P), surface area and porous structure of TiO2 photocatalysts on antibiotic degradation were evidenced. In order to obtain TiO2 photocatalysts with high surface area, this was dispersed on support (zeolite Y, hierarchical zolite Y, MCM-48, SBA-15) and to vary the porous structure, titanium dioxide was obtained by the sol-gel method in the presence of a surfactant (Brij 58) and co-surfactant (active carbon obtained from coffee with different phosphorus content). These materials based on TiO2 were doped with Au, Ag, Fe and were used as photocatalysts in degradation of amoxicillin (AMX), gentamicin (GM), ciprofloxacin (CP) from aqueous solution. Results: The antibiotics photodegradation was evaluated under UV (254 nm) and visible light (532 nm). The best degradation efficiency, Deff (100%) of AMX was obtained for Au-TiO2 supported on MCM-48 mesoporous silica. This result was explained by surface plasmonic effect of Au nanoparticles in interaction with TiO2 (as anatase and rutile, evidenced by XRD and Raman). A similar effect (90% Deff) was achieved, in visible light, for CP photodegradation with Ag-doped mesoporous TiO2. Under similar conditions, in the presence of mesoporous TiO2 with P activated carbon and Ag it was evidenced the absence of antibacterian activity after 5 hours of reaction, suggesting antibiotic degradation. For both, Au and Ag samples, XPS spectra revealed the existence of metal nanoparticles on active surface. A significant effect of mesoporous structure and high surface area on antibiotics degradation was evidenced for similar composition and reaction conditions. Thus, a higher Deff value was obtained for hierarchical zeolite Y compared to zeolite Y. In the case of iron doping, a lower degree of amoxicillin (~40%) release was obtained for both types of zeolite, requiring an increase of iron concentration. For all these applications kinetic studies were performed. These were correlated with the optical, structural and textural properties. Photoluminescence results and measurements of antimicrobial activity revealed different mechanisms of reaction under UV and visible light irradiation. Conclusions: The photocatalytic experiments confirmed the possibility of antibiotics degradation and total reduction of their antimicrobial activity in wastewater.