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SM ISO690:2012 EREMCIUC, Rodica, REVENCO, Ninel. Influence of hypothalamic dysfunctions on growth and puberty in children with juvenile idiopathic arthritis. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 365. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 365-365 | ||||||
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Background. One of the most frequent chronic diseases in children is the juvenile idiopathic arthritis. Chronic inflammatory state, long-term corticosteroid use, undernutrition, and delayed pubertal onset or slow pubertal progression are all factors in the pathogenesis of growth disorders. Objective of the study. Aim of the research is to analyze the influence of autoimmune inflammatory processes on the hypothalamic-pituitary axis, including hormonal and immunological disorders in children with idiopathic juvenile arthritis. Material and Methods. Our study included 90 children from the Rheumatology unit, Mother and Child Healthcare hospital. The research protocol was performed through: observation method, interview, examination, laboratory testing and follow up at 6, 12 and 18 months. All children with growth delay were investigated for growth hormone level and for antipituitary antibodies. Results. General demographic revealed average age 10.52±0,46 years. Data analyse highlights pre-schoolers more susceptible to develop JIA. Gender distribution is 1,09 to 1, female to male ration. Growth impairment was diagnosed in 14,58%. However, girls have more negative values than boys. Risk factors which can impair growth process in children are: younger age at onset of the disease and longer duration of the inflammatory process itself. Growth impairment is more pronounced in systemic onset of JIA. Low serum IGF value was in 17.39% cases. In 3.26% cases was identified low levels of IGF-BP3. 15% of pubertal subjects, have abnormal serum values of gonadotrophes hormones. Conclusion. Management of juvenile idiopathic arthritis in children complicated endocrine comorbidities, can be guided by an individualized approach. In our study, we did not identify any interrelationship between arthritis with growth impairment and hypothalamic-pituitary autoimmunity |
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Cuvinte-cheie Hypothalamic dysfunction, growth, Puberty, children, disfuncție hipotalamică, creştere, pubertate, copii |
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