Articolul precedent |
Articolul urmator |
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SM ISO690:2012 IACOMI, Vladimir, REVENCO, Ninel, EREMCIUC, Rodica, GAIDARJI, Olga. Liver elastography and the jia disease activity: new perspectives. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 364. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 364-364 | ||||||
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Background. Liver injury appreciation in JIA patients with long-term low-dose methotrexate use is still controversial and needs to be screened in large research groups. It is necessary to see its impact on the disease activity. Objective of the study. To appreciate the degree of liver fibrosis in correspondence with the duration of treatment with methotrexate in children with JIA as well as the correlation to its disease activity. Material and Methods. Patients who received low-dose methotrexate greater than six months have been examined by transient unidimensional liver elastography. The M probe was used. The results were referred to the European Federation of Societies for Ultrasound in Medicine and Biology data. Results. Out of 64 patients from the Rheumatology Clinic of the Institute of Mother and Child, Chisinau, Republic of Moldova, who used low-dose methotrexate in JIA, only 43 eligible patients have done liver elastography. It was established about ¾ of them having the liver stiffness median greater than 4,7kPa after 36 weeks of methotrexate use (p < 0,001). It was found an essential decrease in disease activity according to DAS28 in patients with high liver stiffness due to the cumulative methotrexate. Conclusion. Because cumulation of low-dose methotrexate has an impact on the liver toxicity, the use of liver elastography as a non-invasive method of its appreciation makes possible to control the toxicity and the disease activity. |
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Cuvinte-cheie liver elastography, JIA, methotrexate, toxicity, elastografie hepatică, AJI, metotrexat, toxicitate |
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