Articolul precedent |
Articolul urmator |
324 8 |
Ultima descărcare din IBN: 2023-05-19 22:40 |
SM ISO690:2012 CORNEA, Cornelia, ROTARU, Larisa, SASU, Dorian. Hyperuricemia in chronic kidney disease. In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 157. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Pag. 157-157 | ||||||
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Background. Chronic kidney disease (CKD) is a complex of symptoms, the result of the progressive loss of the number of nephrons. In the nephrological practice, patients with CKD represent 2.1-2.6%. It was observed that 20% of people with elevated uric acid developed CKD. Objective of the study. The role of uric acid in chronic kidney disease. Material and Methods. Retrospective and prospective study on a group of 200 CKD patients hospitalized in the Nephrology department of the Republican Clinical Hospital "Timofei Moșneaga", during 2019-2020. The average age of the patients is 58.5 years. The average duration of the disease is 20.5 years. All patients were clinically and paraclinically investigated. Results. The following results were established: distribution by sex - 81% of patients are women and only 19% are men; distribution by nosology - chronic pyelonephritis (PNC) 34%, chronic glomerulonephritis (GC) 17%, diabetic nephropathy (ND) 43%, polycystic kidney 6%; Depending on the cause, chronic kidney disease has a different KDOQI stages: PNC - stage 2 K/DOQI, GC - stage 3 K/DOQI, ND - stage 4 K/DOQI, polycystic kidney – stage 5 K/DOQI. The elevation of uric acid increase depending on the cause and the stage of CKD. Conclusion. With the increase of serum uric acid there is an more severe stage of chronic kidney disease. Finally, intracellular uric acid increases the production of free radicals, thus triggering an inflammatory cascade that eventually results in the formation of fibrosis and glomerulosclerosis. |
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Cuvinte-cheie hyperuricemia, CKD, chronic pyelonephritis, chronic glomerulonephritis, hiperuricemie, BCR, pielonefrită cronică, glomerulonefrită cronică |
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