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SM ISO690:2012 GHELIMICI, Tatiana, LUPAŞCO, Iulianna, DUMBRAVA, Vlada-Tatiana, CHIRVAS, Elena, TARAN, Natalia. Some indicators of the functional condition of the liver and oxidative stress in patients with chronic viral hepatitis . In: Cercetarea în biomedicină și sănătate: calitate, excelență și performanță, Ed. 1, 20-22 octombrie 2021, Chişinău. Chișinău, Republica Moldova: 2021, p. 137. ISBN 978-9975-82-223-7 (PDF).. |
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Cercetarea în biomedicină și sănătate: calitate, excelență și performanță 2021 | ||||||
Conferința "Cercetarea în biomedicină și sănătate: calitate, excelență și performanță" 1, Chişinău, Moldova, 20-22 octombrie 2021 | ||||||
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Background. Chronic HBV and HCV viral infections are able to induce oxidative stress (OS) in infected cells affecting the liver parenchyma with the negative course of the disease. Objective of the study. Study of cytolysis syndrome in patients with chronic viral hepatitis CVH (B, C, mixed B+C) depending on the markers of the SO / AOS system. Material and Methods. The study included 138 patients with CVH B, C, B + C (48.35 ± 2.15 years). Patients were divided into 3 groups: group I - 58 p. with CVH B, group II - 69 p. with CVH C, group III - 11 p. with CVH B + C. ALT, ASAT, markers of the SO / AOS system (ceruloplasmin (CP), superoxidismutase (SOD), malondialdehyde (MDA)) were examined in all patients. The control group (CG) served 30 practically health. Results. Results. The researched study established elevated ALAT values in all examined groups compared to CG values (p˂0.01, p˂0.01, p˂0.01). Cytolysis syndrome resulted in elevated serum levels of CP: versus CG indices (p˂0.05, p˂0.05, p˂0.05). SO manifested by elevated serum MDA levels in all examined groups, being higher in group I -7.12 ± 0.062 nmol / l, versus similar CG values (p˂0.01). These manifestations were accompanied by elevated serum SOD levels in all patients, being the most impressive in group I -52.43 ± 0.87 mgHb compared to the CG results (p≤0.05). Conclusion. In patients with CVH (B, C, B + C), oxidative stress causes a series of metabolic changes against the background of cytolytic syndrome, and disorders of the SO / AOS system. Serum ceruloplasmin in this context may serve as an additional marker of liver fibrosis. |
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Cuvinte-cheie chronic viral hepatitis, ALAT, ASAT, ceruloplasmin, SOD, MDA, hepatita cronică virală, ALAT, ASAT, ceruloplasmină, SOD, MDA |
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