Coordination Compounds of Cu(II), Ni(II) Based on Ethyl 4-benzoate Thiosemicarbazons Derivatives of Salicyl Aldehyde. Antimicrobial and Antifungal Properties
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2024-01-29 09:05
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RUSNAC, Alexandru, BALAN, Greta, GULYA, Aurelian. Coordination Compounds of Cu(II), Ni(II) Based on Ethyl 4-benzoate Thiosemicarbazons Derivatives of Salicyl Aldehyde. Antimicrobial and Antifungal Properties. In: Nanotechnologies and Biomedical Engineering, Ed. 5, 3-5 noiembrie 2021, Chişinău. Chişinău: Pontos, 2021, Ediția 5, p. 114. ISBN 978-9975-72-592-7.
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Nanotechnologies and Biomedical Engineering
Ediția 5, 2021
Conferința "Nanotechnologies and Biomedical Engineering"
5, Chişinău, Moldova, 3-5 noiembrie 2021

Coordination Compounds of Cu(II), Ni(II) Based on Ethyl 4-benzoate Thiosemicarbazons Derivatives of Salicyl Aldehyde. Antimicrobial and Antifungal Properties


Pag. 114-114

Rusnac Alexandru1, Balan Greta2, Gulya Aurelian1
 
1 Moldova State University,
2 ”Nicolae Testemițanu” State University of Medicine and Pharmacy
 
Disponibil în IBN: 18 noiembrie 2021


Rezumat

The article publishes in vitro tests of the antibacterial and antifungal properties of new сoordination compounds of Cu(II), Ni(II) based on ethyl 4-benzoate thiosemicarbazons derivatives of salicyl aldehyde. Two Gram-positive strains were taken as reference strains: Staphylococcus aureus ATCC 25923 and Bacillus cereus ATCC 11778; two Gramnegative strains: E.coli ATCC 25922 and Acinetobacter baumannii BAA-747; three fungal strains: Candida albicans ATCC 10231, Candida krusei ATCC 6258, Cryptococcus neoformans CECT 1043. The best results were recorded at {Ni(HL1)Cl} complex, a selectivity is observed on Cryptococcus neoformans, with CMI = 0.016, CMF = 0.031 mg/mL and is twice as active as the control substance Nystatin. The purity and structural formula of synthesized compounds was confirmed by thin layer chromatography; IR spectroscopy; 1H, 13C Nuclear Magnetic Resonance Spectroscopy, metal analysis and magnetochemical analysis.