Background and aims: We set out to conduct a study to analyze children with CP in order to elucidate some distinct phenotypes. To conduct differential diagnosis between CP and some Neurogenetic pathologies by analyzing the phenotype of patients suspected for PC, with the purpose of assessing the prognosis and improving the care of patients. Methods: A retrospective study was conducted to analyze the history and disease records of children admitted to the neurology sections of the IMSP Institute of Mother and Child of the Republic of Moldova during 2014–2018. All 200 children underwent a complex clinical-paraclinical examination, in addition to performing brain MRI and genetic-molecular examinations. Results: The following pathologies were confirmed among patients suspected of CP: (1) neuronal ceroid lipofuscinosis (1 case), (2) childhood Krabbe disease (1 case), (3) Doparesponsive dystonia (1 case), (4) deficiency glucose transport type 1 (1 case), (5) mitochondrial encephalopathy with lactic acidosis and stroke-like episodes (MELAS) (1 case), (6) Hereditary spastic paraplegia (1 case), (7) spinal amyotrophy ( 2 cases), (8) hereditary myopathy (1 case), (9) Gaucher disease (1 case), (10) Rett syndrome (1 case). Conclusions: Children with CP should be evaluated for some neurogenic disorders, which may mimic a PC. Neuroimaging and molecular-genetic examinations are the ones that help us elucidate the diagnosis. Recognition of the underlying causes of neuro-motor disability will allow improvement in the prognosis, treatment and care of these patients. Specialists in the field should remain cautious in all cases when a PC is suspected, in order to discover the causes of disability. Disclosure: Nothing to disclose