Conţinutul numărului revistei |
Articolul precedent |
Articolul urmator |
485 10 |
Ultima descărcare din IBN: 2024-01-21 15:49 |
Căutarea după subiecte similare conform CZU |
615.012/.014+539.261 (1) |
Farmacologie. Terapeutică. Toxicologie (1592) |
Proprietăţile şi structura sistemelor moleculare (224) |
SM ISO690:2012 UNCU, Livia, EVTODIENCO, Vladilena, MORAR, Ana, CAZACU, Maria, DONICI, Elena. Aplicarea difracţiei cu raze X în cercetarea compatibilităţii substanţelor active cu excipienţii. In: Revista Farmaceutică a Moldovei , 2021, nr. 3(47-S), pp. 23-26. ISSN 1812-5077. |
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Revista Farmaceutică a Moldovei | ||||||
Numărul 3(47-S) / 2021 / ISSN 1812-5077 | ||||||
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CZU: 615.012/.014+539.261 | ||||||
Pag. 23-26 | ||||||
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Rezumat | ||||||
Compatibility studies between active ingredients and excipients in a pharmaceutical form are a key step in the development of a new drug, being applied several methods to investigate potential transformations at the molecular level. In order to evaluate of the possibilities of using X-ray diffraction in researching of the compatibility of active principles with excipients in pharmaceutical forms, an advanced bibliographic study was performed with the evaluation of over 120 sources. In the majority of cases X-ray diffraction has been combined with spectral (FT-IR) and thermal (DSC) methods, being applied only for crystalline substances testing. The identification of crystalline substances by X-ray diffraction with determining of the interplanar distance and the intensity of deviation from these X-ray planes is an advantageous method of detecting incompatibilities. |
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Cuvinte-cheie X-ray diffraction, compatibility, Difracţie cu raze X, compatibilitate |
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